Lonza introduces X-ray powder diffraction at its Monteggio (CH) site
The analytical technique will provide additional information about product quality and stability
Basel, Switzerland, 24 August 2022 – Lonza, a global manufacturing partner to the pharma, biotech and nutrition industries, has expanded the range of particle engineering services offered by its Monteggio (CH) site through the introduction of X-ray powder diffraction (XRPD). This rapid analytical technique provides additional information about the polymorph and solid-state properties of active pharmaceutical ingredients (APIs).
Micronization via jet milling is a well-established technique to control the particle size of APIs and enhance their processing, bioavailability, and dissolution rates. However, as micronization is an energetic process and yields very fine particles, the process may also result in amorphous generation and/or polymorphic changes. These changes can compromise the quality and stability of the product due to the change in its physicochemical properties. Understanding the solid state of materials and identification and characterization by appropriate analytical means are crucial in minimizing stability-related challenges.
The expert team at the Monteggio (CH) site uses a range of analytical techniques to investigate the solid state of crystalline materials. The addition of XRPD complements Lonza’s comprehensive analytical toolbox, allowing the generation of critical data across drug discovery, development, and manufacturing. The XRPD instrument began operations in Q2 2022.
Dirk Knapp, Site Head, Lonza Monteggio, added: “We continue to focus on improving our analytical toolbox to offer a full picture of the quality and stability of crystalline products . The expansion of our analytical capabilities in Monteggio creates a comprehensive offering that brings a multidisciplinary approach to API development and manufacturing.”
For more information on Lonza’s Solid Form Services and Micronization capabilities, visit https://pharma.lonza.com/offerings/small-molecules-and-intermediates/solid-form-services and https://pharma.lonza.com/technologies-products/micronization-and-jet-milling .
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